Aiming at the problem of airspace configuration of AWACS in irregular polygonal responsibility area in air defense operations, based on the real-time detection area formed by the shortest direct flight distance and the smallest turning diameter of the AWACS patrol route, the AWACS responsibility subarea and the corresponding available airspace for AWACS patrol are determined through optimization algorithm. Based on the evaluation criteria of AWACS stability coverage, the airspace configuration is further optimized, and finally the optimization scheme of AWACS airspace configuration is obtained. The feasibility of this method in planning AWACS airspace configuration in irregular polygon responsibility area and the effectiveness of improving operational efficiency are verified by numerical simulation. The method has strong practical value and military value.